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Göteborgs universitets publikationer

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers

Författare och institution:
W. Tajeddinn (-); S. M. Fereshtehnejad (-); M. S. Ahmed (-); T. Yoshitake (-); J. Kehr (-); T. Shahnaz (-); M. Milovanovic (-); H. Behbahani (-); Kina Höglund (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); B. Winblad (-); A. Cedazo-Minguez (-); V. Jelic (-); P. Jaremo (-); D. Aarsland (-)
Publicerad i:
Journal of Alzheimers Disease, 53 ( 2 ) s. 621-630
ISSN:
1387-2877
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Introduction: Serotonin (5-HT) is involved in the pathology of Alzheimer's disease (AD). Objective: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (A beta(42)), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Methods: 15 patients with AD and 20 patients with subjective cognitive impairment (SCI) were included. 5-HT metabolites were measured, in a specific fraction, using high performance liquid chromatography with electrochemical detection (HPLC-ECD). Results: Significantly lower 5-HT concentrations were observed in AD patients compared to SCI patients both after normalization against total protein (p = 0.008) or platelet count (p = 0.019). SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/A beta(42) ratio (p = 0.001), compared to those with high 5-HT levels. Conclusion: AD patients have reduced platelet 5-HT levels. In SCI, lower 5-HT content was associated with a higher AD-CSF biomarker burden.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
Alzheimer's disease, amyloid, cognition, platelet, serotonin, mild cognitive impairment, monoamine-oxidase, blood-platelets, cornell, scale, awake rats, b activity, density, dementia, populations, microdialysis, Neurosciences & Neurology
Postens nummer:
242075
Posten skapad:
2016-09-20 15:50

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