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Assessment of cross-reactivity of new less sensitizing epoxy resin monomers in epoxy resin-allergic individuals

Författare och institution:
Lina Hagvall (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för dermatologi och venereologi); Ida B Niklasson (Institutionen för kemi och molekylärbiologi); Johanna Rudbäck (Institutionen för kemi och molekylärbiologi); Niamh M O'Boyle (Institutionen för kemi och molekylärbiologi); Eva Niklasson (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för dermatologi och venereologi); Kristina Luthman (Institutionen för kemi och molekylärbiologi); Ann-Therese Karlberg (Institutionen för kemi och molekylärbiologi)
Publicerad i:
Contact Dermatitis, 75 ( 3 ) s. 144-150
ISSN:
0105-1873
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
BackgroundMeasures to prevent occupational exposure to epoxy resins, including education, medical examination, and voluntary agreements between employers and workers, have not been effective enough to protect against skin sensitization. Therefore, alternatives to the major epoxy resin haptens that have been found to be less sensitizing in the local lymph node assay have been developed. ObjectivesTo study the cross-reactivity of two newly designed epoxy resin monomers, with decreased skin-sensitizing potency and good technical properties as compared with diglycidyl ether of bisphenol A (DGEBA), in subjects with known contact allergy to epoxy resin of DGEBA type. Patients and MethodsEleven individuals with previous positive patch test reactions to epoxy resin of DGEBA participated in the study. The two alternative epoxy resin monomers were synthesized and patch tested in dilution series in parallel with epoxy resin of DGEBA from the baseline series (containing 92% DGEBA). ResultsAll participants reacted to epoxy resin of DGEBA on retesting. Three participants reacted to monomer 1. No reactions were seen to monomer 2. ConclusionsThe alternative monomers studied showed little or no cross-reactivity with epoxy resin of DGEBA. Decreasing the risk of sensitization by using less sensitizing compounds is important, as contact allergy to epoxy resins is common in spite of thorough preventive measures.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Dermatologi och venereologi
Nyckelord:
allergic contact dermatitis, cross-reactivity, DGEBA, epoxy resin, patch testing, skin sensitization, CONTACT ALLERGY, BISPHENOL-A, DIGLYCIDYL ETHER, GUINEA-PIG, POTENCY, DERMATITIS, RISK, OCCUPATIONS, ELICITATION, INDUCTION
Postens nummer:
241776
Posten skapad:
2016-09-14 12:08

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