transparent gif

 

Ej inloggad.

Göteborgs universitets publikationer

Molecular pathways linking metabolic inflammation and thermogenesis.

Författare och institution:
Giovanni Solinas (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Obesity reviews : an official journal of the International Association for the Study of Obesity, 13 Suppl 2 s. 69-82
ISSN:
1467-789X
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2012
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Obesity is caused by chronic positive energy balance because of higher energy intake relative to energy expenditure. Thermogenesis, the capacity of an organism to produce heat, is an important component of energy expenditure. Thus targeting the molecular mechanisms controlling thermogenesis could be an effective strategy for the prevention or treatment of obesity. Thermogenesis is modulated by three major factors: environmental temperature, nutrient quantity and quality, and by systemic inflammation. Obesity is now recognized to be a state of chronic low-grade systemic inflammation, which has been proposed to play a major role in the pathogenesis of obesity and obesity-associated diseases. This review discussed the molecular pathways that are recruited during metabolic inflammation and that are also implicated in the control of thermogenesis and energy balance. It emerges that the complex signalling network recruited during metabolic inflammation exerts a balanced action on the modulation of thermogenesis and energy balance, with some pathways promoting weight gain whereas other pathways have opposite actions. It is thus concluded that immunomodulation of metabolic inflammation, rather than an anti-inflammatory intervention aiming at its suppression, may be a more promising strategy to increase thermogenesis for the treatment or prevention of obesity and its associated diseases.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper
Nyckelord:
Animals, Cytokines, metabolism, Energy Metabolism, genetics, physiology, Humans, Inflammation, metabolism, Obesity, genetics, physiopathology, prevention & control, Signal Transduction, physiology, Thermogenesis, genetics, physiology
Postens nummer:
241748
Posten skapad:
2016-09-13 18:54

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007