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Göteborgs universitets publikationer

Body composition phenotypes in pathways to obesity and the metabolic syndrome.

Författare och institution:
A G Dulloo (-); J Jacquet (-); Giovanni Solinas (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); J-P Montani (-); Y Schutz (-)
Publicerad i:
International journal of obesity (2005), 34 Suppl 2 s. S4-17
ISSN:
1476-5497
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2010
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Dynamic changes in body weight have long been recognized as important indicators of risk for debilitating diseases. While weight loss or impaired growth can lead to muscle wastage, as well as to susceptibility to infections and organ dysfunctions, the development of excess fat predisposes to type 2 diabetes and cardiovascular diseases, with insulin resistance as a central feature of the disease entities of the metabolic syndrome. Although widely used as the phenotypic expression of adiposity in population and gene-search studies, body mass index (BMI), that is, weight/height(2) (H(2)), which was developed as an operational definition for classifying both obesity and malnutrition, has considerable limitations in delineating fat mass (FM) from fat-free mass (FFM), in particular at the individual level. After an examination of these limitations within the constraints of the BMI-FM% relationship, this paper reviews recent advances in concepts about health risks related to body composition phenotypes, which center upon (i) the partitioning of BMI into an FM index (FM/H(2)) and an FFM index (FFM/H(2)), (ii) the partitioning of FFM into organ mass and skeletal muscle mass, (iii) the anatomical partitioning of FM into hazardous fat and protective fat and (iv) the interplay between adipose tissue expandability and ectopic fat deposition within or around organs/tissues that constitute the lean body mass. These concepts about body composition phenotypes and health risks are reviewed in the light of race/ethnic variability in metabolic susceptibility to obesity and the metabolic syndrome.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper
Nyckelord:
Body Composition, genetics, physiology, Body Mass Index, Cardiovascular Diseases, genetics, prevention & control, Diabetes Mellitus, Type 2, genetics, prevention & control, Female, Genetic Predisposition to Disease, Humans, Male, Malnutrition, genetics, Metabolic Syndrome X, genetics, Obesity, genetics, Phenotype, Risk Factors
Postens nummer:
241741
Posten skapad:
2016-09-13 18:40

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