transparent gif

 

Ej inloggad.

Göteborgs universitets publikationer

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

Författare och institution:
Ryan G. Holzer (-); Eek-Joong Park (-); Ning Li (-); Helen Tran (-); Monica Chen (-); Crystal Choi (-); Giovanni Solinas (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Michael Karin (-)
Publicerad i:
Cell, 147 ( 1 ) s. 173–184
ISSN:
0092-8674
E-ISSN:
1097-4172
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2011
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Saturated fatty acids (FA) exert adverse health effects and are more likely to cause insulin resistance and type 2 diabetes than unsaturated FA, some of which exert protective and beneficial effects. Saturated FA, but not unsaturated FA, activate Jun N-terminal kinase (JNK), which has been linked to obesity and insulin resistance in mice and humans. However, it is unknown how saturated and unsaturated FA are discriminated. We now demonstrate that saturated FA activate JNK and inhibit insulin signaling through c-Src activation. FA alter the membrane distribution of c-Src, causing it to partition into intracellular membrane subdomains, where it likely becomes activated. Conversely, unsaturated FA with known beneficial effects on glucose metabolism prevent c-Src membrane partitioning and activation, which are dependent on its myristoylation, and block JNK activation. Consumption of a diabetogenic high-fat diet causes the partitioning and activation of c-Src within detergent insoluble membrane subdomains of murine adipocytes.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper
Nyckelord:
Lipotoxicity, obesity, insulin resistance, JNK, c-Src
Postens nummer:
241724
Posten skapad:
2016-09-13 16:07

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007