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A role for adipose tissue de-novo lipogenesis in glucose homeostasis during catch-up growth: A Randle cycle favouring fat storage.

Författare och institution:
Helena Marcelino (-); Christelle Veyrat-Durebex (-); Serge Summermatter (-); Delphine Sarafian (-); Jennifer Miles-Chan (-); Denis Arsenijevic (-); Fabio Zani (-); Jean-Pierre Montani (-); Josiane Seydoux (-); Giovanni Solinas (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Abdul G. Dulloo (-)
Publicerad i:
Diabetes, ( 2013 Feb ) s. 362-372
ISSN:
0012-1797
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2013
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue, where de novo lipogenic capacity is concomitantly enhanced. Here we report that isocaloric refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue. These are shown to be early events of catch-up growth that are independent of hyperphagia and precede the development of overt adipocyte hypertrophy, adipose tissue inflammation, or defective insulin signaling. These results suggest a role for enhanced DNL as a glucose sink in regulating glycemia during catch-up growth, which is blunted by exposure to an HF diet, thereby contributing, together with skeletal muscle insulin resistance, to the development of glucose intolerance. Our findings are presented as an extension of the Randle cycle hypothesis, whereby the suppression of DNL constitutes a mechanism by which dietary lipids antagonize glucose utilization for storage as triglycerides in adipose tissue, thereby impairing glucose homeostasis during catch-up growth.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper
Nyckelord:
adipose tissue, diabetes, insulin resistance, lipogenesis, growth
Postens nummer:
241718
Posten skapad:
2016-09-13 15:35

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