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Göteborgs universitets publikationer

Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and CXCR4.

Författare och institution:
André Holdfeldt (Institutionen för medicin); Malene Winther (Institutionen för medicin); Michael Gabl (Institutionen för medicin); Claes Dahlgren (Institutionen för medicin); Huamei Forsman (Institutionen för medicin)
Publicerad i:
Data in brief, 8 s. 411-4
ISSN:
2352-3409
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell functions. Here we include data on human neutrophil function induced by pepducins derived from β2AR (ICL3-8) and CXCR4 (ATI-2341), respectively. ICL3-8 exerts neither direct activating effect on the NADPH-oxidase as measured by superoxide release nor inhibitory effect on FPR signaling. ATI-2341 dose-dependently triggers neutrophil activation and these cells were subsequently desensitized in their response to FPR2 specific agonists F2Pal10 and WKYMVM. Moreover, the ATI-2341 response is inhibited by PBP10 and the peptidomimetic Pam-(Lys-betaNSpe)6-NH2 (both are FPR2 specific inhibitors), but not to the FPR1 specific inhibitor cyclosporine H.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Postens nummer:
241217
Posten skapad:
2016-09-02 16:12

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