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Göteborgs universitets publikationer

Anaesthetics and analgesics; neurocognitive effects, organ protection and cancer reoccurrence an update.

Författare och institution:
I Sellbrant (-); Metha Brattwall (-); Pether Jildenstål (Institutionen för vårdvetenskap och hälsa); Margareta Warrén Stomberg (Institutionen för vårdvetenskap och hälsa); S Forsberg (-); Jan Jakobsson (-)
Publicerad i:
International journal of surgery (London, England), Epub ahead of print ( 34 (2016) ) s. 41-46
ISSN:
1743-9159
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Available general and local anaesthetics, third generation inhaled anaesthetics, propofol and amide class local anaesthetics are effective and reassuringly safe. They are all associated to low incidence of toxicology and or adverse-effects. There is however a debate whether anaesthetic drug and technique could exhibit effects beyond the primary effects; fully reversible depression of the central nervous system, dose dependent anaesthesia. Anaesthetics may be involved in the progression of neurocognitive side effects seen especially in the elderly after major surgery, so called Postoperative Cognitive Dysfunction. On the other hand anaesthetics may exhibit organ protective potential, reducing ischemia reperfusion injury and improving survival after cardiac surgery. Anaesthetics and anaesthetic technique may also have effects of cancer reoccurrence and risk for metastasis. The present paper provides an update around the evidence base around anaesthesia potential contributing effect on the occurrence of postoperative cognitive adverse-effects, organ protective properties and influence on cancer re-occurrence/metastasis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Anestesi och intensivvård
Postens nummer:
240895
Posten skapad:
2016-08-29 13:14
Posten ändrad:
2016-08-31 21:16

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