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Göteborgs universitets publikationer

Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial

Författare och institution:
R. Biemann (-); M. Penner (-); K. Borucki (-); S. Westphal (-); C. Luley (-); R. Ronicke (-); K. Biemann (-); C. Weikert (-); A. Lux (-); N. Goncharenko (-); Hanns-Ulrich Marschall (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); J. G. Schneider (-); B. Isermann (-)
Publicerad i:
Scientific Reports, 6 s. Article number: 30173
ISSN:
2045-2322
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). 74 non-smoking men (45-55 yr) with MetS were randomised to a lifestyle-induced weight loss program (supervision via telemonitoring) or to a control arm. Before and after a 6 months intervention period clinical and laboratory parameters, body composition, serum BA profile, FGF-19, and GLP-1 concentrations were determined in fasting blood samples. 30 participants in the control and 33 participants in the treatment arm completed the study and were included in the data analysis. In participants of the treatment arm lifestyle-induced weight loss resulted in markedly improved insulin sensitivity. Serum levels of BA species and total GLP-1 decreased, while FGF-19 remained stable. Serum BA composition changed towards an increased 12 alpha-hydroxylated/non-12 alpha-hydroxylated ratio. None of these parameters changed in participants of the control arm. Our results demonstrate that improved metabolic control by lifestyle modifications lowers serum levels of BAs and GLP-1 and changes serum BA composition towards an increased 12 alpha/non-12 alpha ratio (ICTRP Trial Number: U1111-1158-3672).
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
y gastric bypass, glucagon-like peptide-1, growth-factor 19, beta-cell, function, metabolic syndrome, insulin sensitivity, glycemic control, gene-expression, obese subjects, glucose, Science & Technology - Other Topics
Postens nummer:
240438
Posten skapad:
2016-08-19 09:12
Posten ändrad:
2016-08-19 13:37

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