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Göteborgs universitets publikationer

Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children

Författare och institution:
Anna Strömbeck (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Anna-Carin Lundell (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Inger Nordström (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Kerstin Andersson (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Ingegerd Adlerberth (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Agnes E Wold (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Anna Rudin (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Clinical & Translational Immunology, 5
ISSN:
2050-0068
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
There are notable inter-individual variations in vaccine-specific antibody responses in vaccinated children. The aim of our study was to investigate whether early-life environmental factors and adaptive immune maturation prior and close to measles-mumps-rubella (MMR) immunization relate to magnitudes of vaccine-specific antibody titers. In the FARMFLORA birth cohort, including both farming and non-farming families, children were immunized with the MMR vaccine at 18 months of age. MMR vaccine-induced antibody titers were measured in plasma samples obtained at 36 months of age. Infants' blood samples obtained at birth, 3-5 days and at 4 and 18 months of age were analyzed for T- and B-cell numbers, proportions of naive and memory T and B cells, and fractions of putative regulatory T cells. Multivariate factor analyses show that higher anti-MMR antibody titers were associated with a lower degree of adaptive immune maturation, that is, lower proportions of memory T cells and a lower capacity of mononuclear cells to produce cytokines, but with higher proportions of putative regulatory T cells. Further, children born by cesarean section (CS) had significantly higher anti-measles titers than vaginally-born children; and CS was found to be associated with delayed adaptive immunity. Also, girls presented with significantly higher anti-mumps and anti-rubella antibody levels than boys at 36 months of age. These results indicate that delayed adaptive immune maturation before and in close proximity to immunization seems to be advantageous for the ability of children to respond with higher anti-MMR antibody levels after vaccination.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Nyckelord:
regulatory t-cells, b-cell, responses, infants, foxp3(+), blood, suppression, proportions, protection, childhood, Immunology
Postens nummer:
240226
Posten skapad:
2016-08-15 10:55
Posten ändrad:
2016-08-15 10:56

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