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Göteborgs universitets publikationer

Weight Loss Interventions and Progression of Diabetic Kidney Disease

Författare och institution:
N. G. Docherty (-); A. L. Canney (-); Carel W le Roux (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning, Avdelningen för gastrokirurgisk forskning och utbildning)
Publicerad i:
Current Diabetes Reports, 15 ( 8 )
ISSN:
1534-4827
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Progressive renal impairment (diabetic kidney disease (DKD)) occurs in upwards of 40 % of patients with obesity and type 2 diabetes mellitus (T2DM) and is a cause of significant morbidity and mortality. Means of attenuating the progression of DKD focus on amelioration of risk factors. Visceral obesity is implicated as a causative agent in impaired metabolic and cardiovascular control in T2DM, and various approaches primarily targeting weight have been examined for their impact on markers of renal injury and dysfunction in DKD. The current report summarises the evidence base for the impact of surgical, lifestyle and pharmacological approaches to weight loss on renal end points in DKD. The potential for a threshold of weight loss more readily achievable by surgical intervention to be a prerequisite for renal improvement is highlighted. Comparing efficacious nonsurgical weight loss strategies with surgical strategies in appropriately powered and controlled prospective studies is a priority for the field.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Invärtesmedicin
Nyckelord:
Kidney, Diabetes, Weight loss, Surgery, Diet, Lifestyle, GFR, Proteinuria, cardiovascular risk-factors, gastric bypass-surgery, bariatric surgery, obese-patients, renal-function, microvascular complications, biliopancreatic diversion, insulin sensitivity, metabolic syndrome, clinical-trial
Postens nummer:
240147
Posten skapad:
2016-08-11 09:19

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