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First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test

Författare och institution:
A. Demir (-); R. Voutilainen (-); U. H. Stenman (-); L. Dunkel (-); Kerstin Albertsson-Wikland (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Ensio Norjavaara (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa)
Publicerad i:
Hormone Research in Paediatrics, 85 ( 5 ) s. 301-308
ISSN:
1663-2818
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Aims: We studied whether first morning voided ( FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the GnRH test in the assessment of the hypothalamic-pituitary-gonadal function in children. Methods: In a single-center study, we compared FMV urinary gonadotropin concentrations with basal and GnRH-stimulated serum gonadotropin levels in 274 children and adolescents (78 girls, 196 boys) aged 5-17 years referred for growth and pubertal disorders. The concordance between FMV urinary gonadotropin concentrations and GnRH test results was assessed. Results: FMV urinary LH (U-LH), urinary FSH (U-FSH) and their ratios correlated well with the corresponding basal and GnRH-stimulated serum parameters (r = 0.66, p < 0.001). Receiver operating characteristic curve analyses using urinary and serum LH and FSH concentrations showed that FMV U-LH and U-LH/U-FSH performed equally well as the GnRH test in the differentiation of early puberty (Tanner stage 2) from prepuberty (Tanner stage 1) (area under the curve 0.768-0.890 vs. 0.712-0.858). FMV U-LH and U-LH/UFSH performed equally well as basal serum LH in predicting a pubertal GnRH test result (area under the curve 0.90-0.93). Conclusion: FMV U-LH determination can be used for the evaluation of pubertal development and its disorders, reducing the need for invasive GnRH stimulation tests. (C) 2016 S. Karger AG, Basel
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Pediatrik
Nyckelord:
Luteinizing hormone, Follicle-stimulating hormone, Gonadotropin-releasing hormone test, Hypothalamic-pituitary-gonadal function, Pubertal disorders, central precocious puberty, hormone-releasing hormone, follicle-stimulating-hormone, luteinizing-hormone, normal-children, immunofluorometric assays, lh-rh, serum, patterns, increase, mir a, 1995, journal of clinical endocrinology & metabolism, v80, p1457, mir a, 1994, pediatric research, v36, p221
Postens nummer:
240125
Posten skapad:
2016-08-10 15:45

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