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Göteborgs universitets publikationer

Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study

Författare och institution:
K. Huus (-); L. Akerman (-); Anders Raustorp (Institutionen för kost- och idrottsvetenskap); J. Ludvigsson (-)
Publicerad i:
Plos One, 11 ( 6 )
ISSN:
1932-6203
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Aim To further elucidate the relationship between physical activity and several risk factors for development of diabetes (glucose, C-peptide and obesity) over time. A prospective longitudinal study where physical activity was measured on 199 children from Kalmar and Linkoping at age 8, and the same 107 children from Linkoping again at age 12. Anthropometric data was collected and blood was analyzed for C-peptide and f-glucose. The children in the study were representative for the general Swedish child population, and on an average lean. High physical activity was related to lower C-peptide at age 8 and 12. This correlation was especially pronounced in boys, who also were more physically active than girls at both time points. The association seen at 8 years of age was similar at age 12 in most children. Children with higher BMI Z-Score had a higher fasting C-peptide (age 12) but linear regression showed that children with more steps per day were less likely to have a higher fasting C-peptide irrespective of BMI. Longitudinal follow-up showed that a decrease in physical activity increased insulin resistance and beta-cell load. Already in young children, physical activity improves insulin sensitivity and decreases the need of C-peptide over time. This seems to become even more pronounced with increasing age when children are followed longitudinally. Low physical activity increases the load on insulin producing beta-cells, might increase the risk for both type 1- and 2 diabetes.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper ->
Näringslära
Nyckelord:
body-mass index, accelerator hypothesis, insulin-secretion, risk-factors, weight-gain, children, childhood, adolescents, obesity, sweden
Postens nummer:
240038
Posten skapad:
2016-08-09 13:44

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