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Göteborgs universitets publikationer

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

Författare och institution:
M. Zietak (-); Petia Kovatcheva-Datchary (Wallenberglaboratoriet & Institutionen för medicin, avdelningen för molekylär och klinisk medicin); L. H. Markiewicz (-); Marcus Ståhlman (Wallenberglaboratoriet & Institutionen för medicin, avdelningen för molekylär och klinisk medicin); L. P. Kozak (-); Fredrik Bäckhed (Wallenberglaboratoriet & Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Cell Metabolism, 23 ( 6 ) s. 1216-1223
ISSN:
1550-4131
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Maintenance of body temperature in cold-exposed animals requires induction of thermogenesis and management of fuel. Here, we demonstrated that reducing ambient temperature attenuated diet-induced obesity (DIO), which was associated with increased iBAT thermogenesis and a plasma bile acid profile similar to that of germ-free mice. We observed a marked shift in the microbiome composition at the phylum and family levels within 1 day of acute cold exposure and after 4 weeks at 12 degrees C. Gut microbiota was characterized by increased levels of Adlercreutzia, Mogibacteriaceae, Ruminococcaceae, and Desulfovibrio and reduced levels of Bacilli, Erysipelotrichaceae, and the genus rc4-4. These genera have been associated with leanness and obesity, respectively. Germ-free mice fed a high-fat diet at room temperature gained less adiposity and improved glucose tolerance when transplanted with caecal microbiota of mice housed at 12 degrees C compared to mice transplanted with microbiota from 29 degrees C. Thus, a microbiota-liver-BAT axis may mediate protection against obesity at reduced temperature.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes
Nyckelord:
brown adipose-tissue, gut microbiota, bile-acids, energy-expenditure, beige fat, thermogenesis, homeostasis, metabolism, activation, crosstalk
Postens nummer:
240031
Posten skapad:
2016-08-09 12:01

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