transparent gif

 

Ej inloggad.

Göteborgs universitets publikationer

Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis

Författare och institution:
Charlotta Eriksson (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Marie Studahl (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Tomas Bergström (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
Journal of Neuroimmunology, 295 s. 130-138
ISSN:
0165-5728
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Herpes simplex encephalitis (HSE) is characterized by a pronounced inflammatory activity in the central nervous system (CNS). Here, we investigated the acute and prolonged complement system activity in HSE patients, by using enzyme-linked immunosorbent assays (ELISAs) for numerous complement components (C). We found increased cerebrospinal fluid concentrations of C3a, C3b, C5 and C5a in HSE patients compared with healthy controls. C3a and C5a concentrations remained increased also compared with patient controls. Our results conclude that the complement system is activated in CNS during HSE in the acute phase, and interestingly also in later stages supporting previous reports of prolonged inflammation. (C) 2016 Elsevier B.V. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Neurologi
Nyckelord:
Complement activation, Herpes simplex virus type 1, Herpes simplex encephalitis, Central nervous system infection, Anaphylatoxins, glycoprotein-c, virus, brain, c3a, pathogenesis, multicenter, meningitis, infections, acyclovir, diagnosis
Postens nummer:
240028
Posten skapad:
2016-08-09 11:51

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007