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Göteborgs universitets publikationer

The landscape of gene fusions and somatic mutations in salivary gland neoplasms - Implications for diagnosis and therapy

Författare och institution:
Mattias K Andersson (Sahlgrenska Cancer Center & Institutionen för biomedicin, avdelningen för patologi); Göran Stenman (Sahlgrenska Cancer Center & Institutionen för biomedicin, avdelningen för patologi)
Publicerad i:
Oral Oncology, 57 s. 63-69
ISSN:
1368-8375
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional coactivators, tyrosine kinase receptors, and other kinases. In addition, next-generation sequencing studies of a few subtypes of salivary neoplasms have revealed hotspot mutations in individual genes and mutations clustering to specific pathways frequently altered in cancer. Although limited, these studies have opened up new avenues for improved classification and targeted therapies of salivary gland cancers. In this review, we summarize the latest developments in this field, focusing on tumor types for which clinically important molecular data are available.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
Chromosome translocations, Gene fusions, Mutation, Biomarker, Salivary gland cancer, Targeted, adenoid cystic carcinoma, nut midline carcinoma, analog secretory, carcinoma, acute lymphoblastic-leukemia, copy number alterations, ex, pleomorphic adenoma, factor-i receptor, duct carcinoma, mucoepidermoid, carcinomas, kinase inhibitor, Oncology, Dentistry
Postens nummer:
240023
Posten skapad:
2016-08-09 11:33
Posten ändrad:
2016-08-18 12:58

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