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Göteborgs universitets publikationer

ESSENCE-Q - a first clinical validation study of a new screening questionnaire for young children with suspected neurodevelopmental problems in south Japan

Författare och institution:
Yuhei Hatakenaka (-); Elisabeth Fernell (Gillbergcentrum); M. Sakaguchi (-); H. Ninomiya (-); I. Fukunaga (-); Christopher Gillberg (Gillbergcentrum)
Publicerad i:
Neuropsychiatric Disease and Treatment, 12 s. 1739-46
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Background: Early identification of autism spectrum disorder, intellectual developmental disorder, attention-deficit/hyperactivity disorder, and other neurodevelopmental disorders/problems is crucial, yet diagnosis is often delayed for years under the often misguided "wait-and-see" paradigm. The early symptomatic syndromes eliciting neurodevelopmental clinical examinations-questionnaire (ESSENCE-Q) is a brief (12-item) screening questionnaire developed specifically for the purpose of speeding up the identification process of a wide variety of neurodevelopmental problems. The aims were to 1) estimate the reliability of the ESSENCE-Q, 2) evaluate the clinical cutoff levels suggested by the author of the ESSENCE-Q, and 3) propose optimal cutoff levels based on receiver operating characteristic analysis. Methods: The ESSENCE-Q was used for 1 year by a psychiatrist in Kochi, Japan, assessing children under the age of 6 years referred for developmental problems. The children were also clinically assessed with regard to whether or not they met criteria for a developmental disorder (diagnosis positive and diagnosis negative groups). We contrasted the results of the ESSENCE-Q and those of clinical diagnostic assessments in 130 cases. Results: Cronbach's alpha was 0.82, sensitivity was 0.94 (95% confidence interval [CI]: [0.88, 0.98]), and specificity 0.53 (95% CI: [0.28, 0.77]), which are reasonable psychometrics for a first-step screening tool. Based on receiver operating characteristic analysis, we recommended an optimal cutoff level of yes >= 2 or maybe/a little >= 3 on the ESSENCE-Q (0.87 (95% CI: [0.79, 0.92]) sensitivity and 0.77 (95% CI: [0.50, 0.93]) specificity). Conclusion and implication: The ESSENCE-Q can be a good instrument for use as a screening tool for aiding in the process of early identification of neurodevelopmental disorders in clinical settings. To establish the broader validity and reliability of the ESSENCE-Q, case-control studies and general population studies of children in different age groups are needed.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
ESSENCE, ESSENCE-Q, cutoff levels, receiver operating characteristic analysis, autism spectrum disorders, attentional deficits, developmental delay, diagnosis, validity, motor, Neurosciences & Neurology, Psychiatry
Postens nummer:
Posten skapad:
2016-08-05 14:30
Posten ändrad:
2016-08-18 11:36

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