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Göteborgs universitets publikationer

The role of membrane ER alpha signaling in bone and other major estrogen responsive tissues

Författare och institution:
Karin L. Gustafsson (Centre for Bone and Arthritis Research); Helen H. Farman (Centre for Bone and Arthritis Research); Petra Henning (Centre for Bone and Arthritis Research); Vikte Lionikaite (Centre for Bone and Arthritis Research); Sofia Movérare-Skrtic (Centre for Bone and Arthritis Research); Jianyao Wu (Centre for Bone and Arthritis Research); Henrik Ryberg (Centre for Bone and Arthritis Research); A. Koskela (-); J. A. Gustafsson (-); J. Tuukkanen (-); E. R. Levin (-); Claes Ohlsson (Centre for Bone and Arthritis Research); Marie K Lagerquist (Centre for Bone and Arthritis Research)
Publicerad i:
Scientific Reports, 6 s. Article number: 29473
ISSN:
2045-2322
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Estrogen receptor a (ER alpha) signaling leads to cellular responses in several tissues and in addition to nuclear ER alpha-mediated effects, membrane ER alpha (mER alpha) signaling may be of importance. To elucidate the significance, in vivo, of mER alpha signaling in multiple estrogen-responsive tissues, we have used female mice lacking the ability to localize ER alpha to the membrane due to a point mutation in the palmitoylation site (C451A), so called Nuclear-Only-ER (NOER) mice. Interestingly, the role of mER alpha signaling for the estrogen response was highly tissue-dependent, with trabecular bone in the axial skeleton being strongly dependent (>80% reduction in estrogen response in NOER mice), cortical and trabecular bone in long bones, as well as uterus and thymus being partly dependent (40-70% reduction in estrogen response in NOER mice) and effects on liver weight and total body fat mass being essentially independent of mER alpha (<35% reduction in estrogen response in NOER mice). In conclusion, mER alpha signaling is important for the estrogenic response in female mice in a tissue-dependent manner. Increased knowledge regarding membrane initiated ER alpha actions may provide means to develop new selective estrogen receptor modulators with improved profiles.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
receptor-alpha, mice, nuclear, extranuclear, beta, localization, profile, update, health, growth, Science & Technology - Other Topics
Postens nummer:
239792
Posten skapad:
2016-08-04 17:29
Posten ändrad:
2016-08-18 10:36

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