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Göteborgs universitets publikationer

Serum vitamin D (25OHD(3)) levels and the risk of different subtypes of breast cancer: A nested case-control study

Författare och institution:
L. Shirazi (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning); M. Almquist (-); S. Borgquist (-); J. Malm (-); J. Manjer (-)
Publicerad i:
Breast, 28 s. 184-190
ISSN:
0960-9776
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Background: Previous studies regarding the association between serum 25-hydroxyvitamin D (25OHD(3)) and breast cancer risk have not been conclusive. The aim of this study was to investigate the potential association between pre-diagnostic serum 25OHD(3) levels and the risk of different subtypes of breast cancer. Materials and methods: The study was based on The Malmo Diet and Cancer Study recruiting 17,035 women from 1991 to 1996. A total of 764 incident breast cancers with matched controls were analysed for 25OHD(3) in samples collected at baseline, before diagnosis. A logistic regression analysis was used to calculate odds ratios with 95% confidence intervals for tertiles of 25OHD(3) in relation to different subtypes of breast cancer, i.e. defined according to tumour type, tumour size, lymph node involvement, histological grade, oestrogen receptor (ER) status, progesterone receptor (PgR) status, Ki67, cyclin D1 and p27. Results: As compared to the 1st tertile of 25OHD(3), the second tertile had a statistically significantly lower risk of ER negative tumours, PgR negative tumours and tumours with a high expression of Ki67, A similar pattern was seen in relation to large tumours (>= 21 mm), grade III tumours, and tumours with low p27 expression, but these associations did not reach statistical significance. The third tertile had a similar risk as the first tertile. Conclusions: We found that women with low levels of 25OHD(3), as compare to women in the middle tertile, had a high risk of breast tumours with an unfavourable prognosis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Cancer och onkologi
Nyckelord:
Breast cancer, Tumour size, Oestrogen receptor status, Progesterone receptor status, Ki67, Vitamin D, plasma 25-hydroxyvitamin d, african-american women, prediagnostic serum, clinical-trial, calcium, health, cohort, metaanalysis, association, prevention, Oncology, Obstetrics & Gynecology
Postens nummer:
239780
Posten skapad:
2016-08-04 16:21

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