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Göteborgs universitets publikationer

Effect of Visit-to-Visit Variation of Heart Rate and Systolic Blood Pressure on Outcomes in Chronic Systolic Heart Failure: Results From the Systolic Heart Failure Treatment With the I-f Inhibitor Ivabradine Trial (SHIFT) Trial

Författare och institution:
M. Bohm (-); M. Robertson (-); J. Borer (-); I. Ford (-); M. Komajda (-); F. Mahfoud (-); S. Ewen (-); Karl Swedberg (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); L. Tavazzi (-)
Publicerad i:
Journal of the American Heart Association, 5 ( 2 ) s. e002160
ISSN:
2047-9980
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Background-Elevated resting heart rate (HR) and low systolic blood pressure (SBP) are related to poor outcomes in heart failure (HF). The association between visit-to-visit variation in SBP and HR and risk in HF is unknown. Methods and Results-In Systolic Heart Failure Treatment with the I-f inhibitor ivabradine Trial (SHIFT) patients, we evaluated relationships between mean HR, mean SBP, and visit-to-visit variations (coefficient of variation [CV]=SD/meanx100%) in SBP and HR (SBP-CV and HR-CV, respectively) and primary composite endpoint (cardiovascular mortality or HF hospitalization), its components, all-cause mortality, and all-cause hospitalization. High HR and low SBP were closely associated with risk for primary endpoint, all-cause mortality, and HF hospitalization. The highest number of primary endpoint events occurred in the highest HR tertile (38.8% vs 16.4% lowest tertile; P<0.001). For HR-CV, patients at highest risk were those in the lowest tertile. Patients in the lowest thirds of mean SBP and SBP-CV had the highest risk. The combination of high HR and low HR-CV had an additive deleterious effect on risk, as did that of low SBP and low SBP-CV. Ivabradine reduced mean HR and increased HR-CV, and increased SBP and SBP-CV slightly. Conclusions-Beyond high HR and low SBP, low HR-CV and low SBP-CV are predictors of cardiovascular outcomes with additive effects on risk in HF, but with an unknown effect size. Beyond HR reduction, ivabradine increases HR-CV. Low visit-to-visit variation of HR and SBP might signal risk of cardiovascular outcomes in systolic HF.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kardiologi
Nyckelord:
blood pressure, heart failure, heart rate-blood pressure variation, all-cause mortality, cardiovascular-disease, episodic hypertension, prognostic value, day variability, risk, metaanalysis, association, predictor, efficacy, Cardiovascular System & Cardiology
Postens nummer:
239570
Posten skapad:
2016-07-27 16:26
Posten ändrad:
2016-08-16 11:03

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