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Göteborgs universitets publikationer

Hepatic insulin-like growth factor binding protein (igfbp) responses to food restriction in Atlantic salmon smolts

Författare och institution:
J. P. Breves (-); S. K. Phipps-Costin (-); C. K. Fujimoto (-); Ingibjörg Einarsdottir (Institutionen för biologi och miljövetenskap); A. M. Regish (-); Björn Thrandur Björnsson (Institutionen för biologi och miljövetenskap); S. D. McCormick (-)
Publicerad i:
General and Comparative Endocrinology, 233 s. 79-87
ISSN:
0016-6480
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The growth hormone (Gh)/insulin-like growth-factor (Igf) system plays a central role in the regulation of growth in fishes. However, the roles of Igf binding proteins (Igfbps) in coordinating responses to food availability are unresolved, especially in anadromous fishes preparing for seaward migration. We assayed plasma Gh, Igf1, thyroid hormones and cortisol along with igfbp mRNA levels in fasted and fed Atlantic salmon (Salmo solar). Fish were fasted for 3 or 10 days near the peak of smoltification (late April to early May). Fasting reduced plasma glucose by 3 days and condition factor by 10 days. Plasma Gh, cortisol, and thyroxine (T-4) were not altered in response to fasting, whereas Igf1 and 3,5,3'-triiodo-L-thyronine (T-3) were slightly higher and lower than controls, respectively. Hepatic igfbp1b1, -1b2, -2a,-2b1 and -2b2 mRNA levels were not responsive to fasting, but there were marked increases in igfbp1a1 following 3 and 10 days of fasting. Fasting did not alter hepatic igf1 or igf2; however, muscle igf1 was diminished by 10 days of fasting. There were no signs that fasting compromised branchial ionoregulatory functions, as indicated by unchanged Na+/K+-ATPase activity and ion pump/transporter mRNA levels. We conclude that dynamic hepatic igfbp1a1 and muscle igf1 expression participate in the modulation of Gh/Igf signaling in smolts undergoing catabolism.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Geovetenskap och miljövetenskap
NATURVETENSKAP ->
Biologiska vetenskaper
Nyckelord:
Insulin-like growth-factor, Binding proteins, Growth hormone, Atlantic salmon, Liver, Fasting, trout oncorhynchus-mykiss, messenger-rna expression, rainbow-trout, coho, salmon, factor-i, skeletal-muscle, gene-expression, post-smolts, na+,k+,2cl(-) cotransporter, transcriptional regulation, Endocrinology & Metabolism
Postens nummer:
239508
Posten skapad:
2016-07-26 16:35

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