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Göteborgs universitets publikationer

Temporal Rewiring of Striatal Circuits Initiated by Nicotine.

Författare och institution:
Louise Adermark (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Julia Morud (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Amir Lotfi (Institutionen för neurovetenskap och fysiologi); Klara Danielsson (-); Lisa Ulenius (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Bo Söderpalm (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Mia Ericson (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi)
Publicerad i:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Epub ahead of print
ISSN:
1740-634X
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Drug addiction has been conceptualized as maladaptive recruitment of integrative circuits coursing through the striatum, facilitating drug seeking and drug taking behavior. The aim of this study was to define temporal neuroadaptations in striatal subregions initiated by three weeks of intermittent nicotine exposure followed by protracted abstinence. Enhanced rearing activity was assessed in motor activity boxes as a measurement of behavioral change induced by nicotine (0.36 mg/kg), while electrophysiological field potential recordings were performed to evaluate treatment effects on neuronal activity. Dopamine receptor mRNA expression was quantified by qPCR, and nicotine-induced dopamine release measured in striatal subregions using in vivo microdialysis. Golgi staining was performed to assess nicotine-induced changes in spine density of medium spiny neurons (MSNs). The data presented here shows that a brief period of nicotine exposure followed by abstinence leads to temporal changes in synaptic efficacy, dopamine receptor expression and spine density in a subregion specific manner. Nicotine may thus initiate a reorganization of striatal circuits that continues to develop despite protracted abstinence. We also show that the response to nicotine is modulated in previously exposed rats even after 6 months of abstinence. The data presented here suggests that, even though not self-administered, nicotine may produce progressive neuronal alterations in brain regions associated with goal-directed and habitual performance, which might contribute to the development of compulsive drug seeking and the increased vulnerability to relapse, which are hallmarks of drug addiction.Neuropsychopharmacology accepted article preview online, 08 July 2016. doi:10.1038/npp.2016.118.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Neurovetenskaper ->
Neurovetenskap
Postens nummer:
239391
Posten skapad:
2016-07-17 14:10
Posten ändrad:
2016-08-12 14:38

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