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Göteborgs universitets publikationer

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

Författare och institution:
Liping Hou (-); Sarah E Bergen (-); Nirmala Akula (-); Jie Song (-); Christina M Hultman (-); Mikael Landén (Institutionen för neurovetenskap och fysiologi); Mazda Adli (-); Martin Alda (-); Raffaella Ardau (-); Bárbara Arias (-); Jean-Michel Aubry (-); Lena Backlund (-); Judith A Badner (-); Thomas B Barrett (-); Michael Bauer (-); Bernhard T Baune (-); Frank Bellivier (-); Antonio Benabarre (-); Susanne Bengesser (-); Wade H Berrettini (-); Abesh Kumar Bhattacharjee (-); Joanna M Biernacka (-); Armin Birner (-); Cinnamon S Bloss (-); Clara Brichant-Petitjean (-); Elise T Bui (-); William Byerley (-); Pablo Cervantes (-); Caterina Chillotti (-); Sven Cichon (-); Francesc Colom (-); William Coryell (-); David W Craig (-); Cristiana Cruceanu (-); Piotr M Czerski (-); Tony Davis (-); Alexandre Dayer (-); Franziska Degenhardt (-); Maria Del Zompo (-); J Raymond DePaulo (-); Howard J Edenberg (-); Bruno Étain (-); Peter Falkai (-); Tatiana Foroud (-); Andreas J Forstner (-); Louise Frisén (-); Mark A Frye (-); Janice M Fullerton (-); Sébastien Gard (-); Julie S Garnham (-); Elliot S Gershon (-); Fernando S Goes (-); Tiffany A Greenwood (-); Maria Grigoroiu-Serbanescu (-); Joanna Hauser (-); Urs Heilbronner (-); Stefanie Heilmann-Heimbach (-); Stefan Herms (-); Maria Hipolito (-); Shashi Hitturlingappa (-); Per Hoffmann (-); Andrea Hofmann (-); Stephane Jamain (-); Esther Jiménez (-); Jean-Pierre Kahn (-); Layla Kassem (-); John R Kelsoe (-); Sarah Kittel-Schneider (-); Sebastian Kliwicki (-); Daniel L Koller (-); Barbara König (-); Nina Lackner (-); Gonzalo Laje (-); Maren Lang (-); Catharina Lavebratt (-); William B Lawson (-); Marion Leboyer (-); Susan G Leckband (-); Chunyu Liu (-); Anna Maaser (-); Pamela B Mahon (-); Wolfgang Maier (-); Mario Maj (-); Mirko Manchia (-); Lina Martinsson (-); Michael J McCarthy (-); Susan L McElroy (-); Melvin G McInnis (-); Rebecca McKinney (-); Philip B Mitchell (-); Marina Mitjans (-); Francis M Mondimore (-); Palmiero Monteleone (-); Thomas W Mühleisen (-); Caroline M Nievergelt (-); Markus M Nöthen (-); Tomas Novák (-); John I Nurnberger (-); Evaristus A Nwulia (-); Urban Ösby (-); Andrea Pfennig (-); James B Potash (-); Peter Propping (-); Andreas Reif (-); Eva Reininghaus (-); John Rice (-); Marcella Rietschel (-); Guy A Rouleau (-); Janusz K Rybakowski (-); Martin Schalling (-); William A Scheftner (-); Peter R Schofield (-); Nicholas J Schork (-); Thomas G Schulze (-); Johannes Schumacher (-); Barbara W Schweizer (-); Giovanni Severino (-); Tatyana Shekhtman (-); Paul D Shilling (-); Christian Simhandl (-); Claire M Slaney (-); Erin N Smith (-); Alessio Squassina (-); Thomas Stamm (-); Pavla Stopkova (-); Fabian Streit (-); Jana Strohmaier (-); Szabolcs Szelinger (-); Sarah K Tighe (-); Alfonso Tortorella (-); Gustavo Turecki (-); Eduard Vieta (-); Julia Volkert (-); Stephanie H Witt (-); Adam Wright (-); Peter P Zandi (-); Peng Zhang (-); Sebastian Zollner (-); Francis J McMahon (-)
Publicerad i:
Human molecular genetics, Epub ahead of print
ISSN:
1460-2083
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87 × 10(-9); odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53 × 10(-9); odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Psykiatri
Postens nummer:
239372
Posten skapad:
2016-07-14 08:21
Posten ändrad:
2016-08-12 14:10

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