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Göteborgs universitets publikationer

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape.

Författare och institution:
Kenneth Blum (-); Marcelo Febo (-); Rajendra D Badgaiyan (-); Zsolt Demetrovics (-); Thomas Simpatico (-); Claudia Fahlke (Psykologiska institutionen); M Oscar-Berman (-); Mona Li (-); Kristina Dushaj (-); Mark S Gold (-)
Publicerad i:
Current neuropharmacology, Epub ahead of print
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed "Brain Reward Cascade." These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance) termed "Reward Deficiency Syndrome" (RDS), which incorporates a complex multifaceted array of inheritable behaviors that are polygenic. In this review article, we attempt to clarify these terms and provide a working model to accurately diagnose and treat these unwanted behaviors. We are hereby proposing the development of a translational model we term "Reward Deficiency Syndrome Solution System™" that incorporates neurogenetic testing and meso-limbic manipulation of a "hypodopaminergic" trait/state, which provides dopamine agonistic modality (DAM) as well as reduced "dopamine resistance," while embracing "dopamine homeostasis." The result is better recovery and relapse prevention, despite DNA antecedents, which could impact the recovery process and relapse. Understanding the commonality of mental illness will morph erroneous labeling based on symptomatology, rather than genetic and anatomical etiology. WC: 180.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Postens nummer:
Posten skapad:
2016-07-12 00:26
Posten ändrad:
2016-07-13 13:11

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