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Göteborgs universitets publikationer

Cysteine residues reduce the severity of dopamine electrochemical fouling

Författare och institution:
Wolfgang Harreither (Institutionen för kemi och molekylärbiologi); Raphaël Trouillon (-); Philippe Poulin (-); Wilfrid Neri (-); Andrew G Ewing (Institutionen för kemi och kemiteknik, Analytisk kemi, Chalmers & Institutionen för kemi och molekylärbiologi); Gulnara Safina (Institutionen för kemi och molekylärbiologi)
Publicerad i:
Electrochimica Acta, 210 s. 622-629
ISSN:
0013-4686
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The fouling of neurotransmitter during electrochemical detection can dramatically jeopardize the viability of the sensor. Several recent developments in electrode fabrication and design have helped mitigating this issue. For instance, carbon nanotube fiber (CNTF) electrodes were found to be more resistant to fouling than the traditional carbon fiber (CF) electrodes. Here, we investigate the fouling resistance of these two materials in the presence of albumin. Interestingly, our data shows that the presence of albumin reduces the impact of dopamine (DA) fouling in a dose-dependent manner. A protective effect from DA fouling was also observed for other thiol containing substances, thus hinting that the sulfur competes with the amine moiety for the nucleophilic binding to the oxidized catechol, a critical step initiating DA fouling, and therefore reduces the rate of DA polymerization on the electrode surface. Overall, this study furthers our understanding of the mechanisms controlling DA detection in situ, and suggests using solutions of albumin as a background for calibrating sensors.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Kemi ->
Analytisk kemi ->
Elektrokemi
Nyckelord:
carbon fiber; carbon nanotube fiber; dopamine; electrochemical fouling; microelectrode
Postens nummer:
239180
Posten skapad:
2016-07-08 10:51
Posten ändrad:
2016-09-19 14:49

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