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Urinary Mineral Concentrations in European Pre-Adolescent Children and Their Association with Calcaneal Bone Quantitative Ultrasound Measurements

Författare och institution:
K. Van den Bussche (-); D. Herrmann (-); S. De Henauw (-); Y. A. Kourides (-); F. Lauria (-); Staffan Mårild (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik); D. Molnar (-); L. A. Moreno (-); T. Veidebaum (-); W. Ahrens (-); I. Sioen (-)
Publicerad i:
International Journal of Environmental Research and Public Health, 13 ( 5 ) s. Article number: 471
ISSN:
1660-4601
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1-11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
potassium, sodium, calcium, magnesium, phosphate, children, calcaneal quantitative ultrasound, base-line survey, renal acid load, potassium excretion, creatinine, concentrations, socioeconomic-status, childhood obesity, reference, values, young females, salt intake, idefics, Environmental Sciences & Ecology
Postens nummer:
238959
Posten skapad:
2016-07-05 12:53
Posten ändrad:
2016-07-06 09:12

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