transparent gif

 

Ej inloggad.

Göteborgs universitets publikationer

Stationary mutation models

Författare och institution:
Ivar Simonsson (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU); Petter Mostad (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU)
Publicerad i:
Forensic Science International-Genetics, 23 s. 217-225
ISSN:
1872-4973
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Probability calculations for relationship inference based on DNA tests are often performed with computer packages such as Familias. When mutations are assumed to be a possibility, one may notice a curious and problematic effect of including untested parents: results tend to change slightly. In this paper, we trace this effect back to fundamental model-formulating issues which can only be resolved by using stationary mutation models. We present several methods for obtaining such stationary mutation matrices from original mutation matrices, and evaluate essential properties of these methods. Our conclusion is that typically, stationary mutation models can be obtained, but for many types of markers, it may be impossible to combine specific biologically reasonable requirements for a mutation matrix with the requirement of stationarity.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Matematik
Nyckelord:
Familias, DNA relationship inference, STR markers, Mutation matrices, Genetics & Heredity, Legal Medicine
Postens nummer:
238836
Posten skapad:
2016-07-04 09:03
Posten ändrad:
2016-08-10 11:05

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007