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Göteborgs universitets publikationer

Refill Adherence in Relation to Substitution and the Use of Multiple Medications: A Nationwide Population Based Study on New ACE-Inhibitor Users

Författare och institution:
P. J. Bjerkeli (-); A. K. Jonsson (-); Eva Lesén (-); Ann-Charlotte Mårdby (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Karolina Andersson Sundell (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa)
Publicerad i:
Plos One, 11 ( 5 )
ISSN:
1932-6203
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Objective Generic substitution has contributed to economic savings but switching products may affect patient adherence, particularly among those using multiple medications. The aim was to analyse if use of multiple medications influenced the association between switching products and refill adherence to angiotensin-converting-enzyme (ACE) inhibitors in Sweden. New users of ACE-inhibitors, starting between 1 July 2006 and 30 June 2007, were identified in the Swedish Prescribed Drug Register. Refill adherence was assessed using the continuous measure of medication acquisition (CMA) and analysed with linear regression and analysis of covariance. The study population included 42735 individuals whereof 51.2% were exposed to switching ACE-inhibitor and 39.6% used multiple medications. Refill adherence was higher among those exposed to switching products than those not, but did not vary depending on the use of multiple medications or among those not. Refill adherence varied with age, educational level, household income, country of birth, previous hospitalisation and previous cardiovascular diagnosis. The results indicate a positive association between refill adherence and switching products, mainly due to generic substitution, among new users of ACE-inhibitors in Sweden. This association was independent of use of multiple medications.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Farmaceutisk vetenskap
Nyckelord:
GENERIC SUBSTITUTION, HYPERTENSION, THERAPY, IMPACT, PHARMACEUTICALS, ASSOCIATION, EXPERIENCES, PERSISTENCE, PREDICTORS, ATTITUDES
Postens nummer:
238437
Posten skapad:
2016-06-28 10:23

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