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Göteborgs universitets publikationer

Cadmium exposure as measured in blood in relation to macrophage density in symptomatic atherosclerotic plaques from human carotid artery

Författare och institution:
Björn Fagerberg (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet); Josefin Kjelldahl (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet); Gerd Sallsten (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin); Lars Barregård (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin); N. Forsgard (-); Klas Österberg (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet); Lillemor Mattsson Hultén (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet); Göran Bergström (Institutionen för medicin, avdelningen för molekylär och klinisk medicin & Wallenberglaboratoriet)
Publicerad i:
Atherosclerosis, 249 s. 209-214
ISSN:
0021-9150
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Background and Aims: The general population is exposed to cadmium through diet and smoking. Cadmium is pro-atherogenic and pro-inflammatory in experimental and observational studies. Cadmium levels in blood and carotid plaque endarterectomies correlate. Cadmium concentrations are much higher in plaque-areas that most frequently rupture. Here we investigated if blood cadmium concentrations are associated with macrophage density and the accumulation of CD14 as indicator of macrophage activation by lipopolysaccharide (LPS) in endarterectomies from patients with symptomatic carotid plaques. Methods: Endarterectomies from ninety nine patients were fixed in formalin, embedded in paraffin, serially sectioned and stained for assessment of morphology. As predefined, the two section levels with most prevalent plaque rupture were used for further analyses. Macrophages were assessed as area of staining for CD68 (%). Blood cadmium was measured with ICP-MS. Results: The CD68 median [25,75 percentiles] from the average of both sections were higher in cadmium tertile 3 than in tertile 1 (9.8 [4.9,16.1] % and 3.8 (0.6,12.4) %, p = 0.017). This difference remained in a multiple linear regression analysis with 10log meanCD68 as dependent variable and adjustment for sex, age, smoking, statin treatment, index event, time between event and surgery (beta coefficient 0.44 [95% CI 0.05-0.87]. CD14 was not associated with blood cadmium. Conclusions: The results showed that blood cadmium was associated with proinflammatory macrophage density in the sections of carotid plaques with most frequent rupture, previously shown to contain most cadmium. No association between cadmium and LPS-mediated macrophage-activation was found. Cadmium exposure may promote plaque inflammation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Medicinsk genetik ->
Molekylär medicin (genetik och patologi)
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kardiologi ->
Kardiovaskulär medicin
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper ->
Miljömedicin och yrkesmedicin ->
Miljömedicin
Nyckelord:
Cadmium, Carotid artery, Cardiovascular disease, Atherosclerosis, Plaque, Macrophage, Inflammation, CARDIOVASCULAR-DISEASE, INFLAMMATION, STABILIZATION, ASSOCIATION, MORTALITY, STROKE, EXPRESSION, DIRECTION, UPSTREAM, LESIONS
Postens nummer:
238314
Posten skapad:
2016-06-27 10:54
Posten ändrad:
2016-06-27 10:55

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