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Göteborgs universitets publikationer

Considerably decreased risk of cardiovascular disease with combined reductions in HbA1c, blood pressure and blood lipids in type 2 diabetes: Report from the Swedish National Diabetes Register

Författare och institution:
Katarina Eeg-Olofsson (Institutionen för medicin); B. Zethelius (-); Soffia Gudbjörnsdottir (Institutionen för medicin); Björn Eliasson (Institutionen för medicin); Ann-Marie Svensson (Institutionen för medicin); J. Cederholm (-)
Publicerad i:
Diabetes & Vascular Disease Research, 13 ( 4 ) s. 268-277
ISSN:
1479-1641
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Objectives: Assess the effect of risk factors changes on risk for cardiovascular disease and mortality in patients with type 2 diabetes selected from the Swedish National Diabetes Register. Methods: Observational study of 13,477 females and males aged 30-75years, with baseline HbA1c 41-67mmol/mol, systolic blood pressure 122-154mmHg and ratio non-HDL:HDL 1.7-4.1, followed for mean 6.5years until 2012. Four groups were created: a reference group (n=6757) with increasing final versus baseline HbA1c, systolic blood pressure and non-HDL:HDL cholesterol during the study period, and three groups with decreasing HbA1c (n=1925), HbA1c and systolic blood pressure (n=2050) or HbA1c and systolic blood pressure and non-HDL:HDL (n=2745). Results: Relative risk reduction for fatal/nonfatal cardiovascular disease was 35% with decrease in HbA1c only (mean 6 to final 49mmol/mol), 56% with decrease in HbA1c and systolic blood pressure (mean 12 to final 128mmHg) and 75% with combined decreases in HbA1c, systolic blood pressure and non-HDL:HDL (mean 0.8 to final 2.1), all p<0.001 adjusting for clinical characteristics, other risk factors, treatments and previous cardiovascular disease. Similar risk reductions were found for fatal/nonfatal coronary heart disease, fatal cardiovascular disease, all-cause mortality and also in a subgroup of 3038 patients with albuminuria. Conclusion: Considerable risk reductions for cardiovascular disease and mortality were seen with combined long-term risk factor improvement.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Kardiologi ->
Kardiovaskulär medicin
Nyckelord:
Blood lipids, blood pressure, cardiovascular diseases, diabetes mellitus, HbA1c, coronary-artery-disease, myocardial-infarction, prospective cohort, heart-disease, united-states, sweden, complications, hemoglobin, glycemia, association, Endocrinology & Metabolism, Cardiovascular System & Cardiology
Postens nummer:
238207
Posten skapad:
2016-06-23 13:54
Posten ändrad:
2016-06-23 13:55

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