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Göteborgs universitets publikationer

Multiparametric MRI (mpMRI) for spatiotemporal characterization of tumor tissue response to radionuclide treatment

Författare och institution:
Mikael Montelius (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik); Johan Spetz (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik & Sahlgrenska Cancer Center); Maria Ljungberg (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik); Eva Forssell-Aronsson (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik & Sahlgrenska Cancer Center)
Publicerad i:
62nd Annual International Meeting Radiation Research Society, Waikoloa, HI, USA, October 16-19, 2016,
Publikationstyp:
Konferensbidrag - refereegranskat abstract
Publiceringsår:
2016
Språk:
engelska
Sammanfattning (abstract):
Background: Development and optimization of efficient tumor treatment methods are needed. Increased understanding of the complex and heterogeneous tumor microenvironment in response to treatment is thus required, necessitating multiple, non-invasive biomarker acquisition with spatiotemporal resolution. mpMRI potentially offers methods with the required capabilities. Aim: To assess the possibility to non-invasively retrieve multiple, complementary information on radionuclide treatment effects on tumor microenvironment, using spatiotemporally resolved mpMRI. Methods: 19 mice with neuroendocrine tumors (~1 cm) received 15 MBq 177Lu-octreotate i.v. on day 0 (tumor dose ~4 Gy) and were imaged on day -1, 1, 3, 8 and 13. Imaging included IVIM (reflecting apoptosis/necrosis (AN) and capillary activity (CA)) [1], T1/T2* mapping (microstructural alterations (MA) and hypoxia/hemorrhage (HH)), DCE (microvessel integrity/perfusion tracer kinetics (IK)) and T2w MRI (morphology/size). Matlab based post-processing included voxelwise model fitting and tumor delineation to define a binary mask for volumetry and parameter extraction. An automatic separation of the mask into annular disks of preserved tumor shape but stepwise decreased size was performed, allowing separate regional analyses of central to peripheral parts of the tumor. Results: Groups with high/low response (HRG n = 8/LRG n = 4), based on post-treatment tumor volume (monotonically decreasing/increasing days 1-13) were identified. Post-treatment changes with significant separation of HRG from LRG (p < 0.05) were found in parameters related to AN: 1‡ parameter, CA: 1‡, HH: 1, IK: 10 (3†, 7‡) and MA: 1. Pre-treatment HRG/LRG prediction was possible in all 15 (8†) parameters; AN: 1, CA: 1, HH: 1, IK: 11 (8†) and MA: 1. (†Only after spatial separation. ‡Only transiently). Conclusions: Multiple, complementary biomarker information related to radionuclide tumor treatment could be extracted using spatiotemporally resolved mpMRI. Several parameters required separate analysis of sub-tumoural regions in order to separate high from low responding tumors, and some were only transiently affected, highlighting the importance of repeated measurements with spatially resolved techniques. References: 1. Le Bihan et al. Radiology, 1988
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Cancer och onkologi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Radiologi och bildbehandling ->
Diagnostisk radiologi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Radiologi och bildbehandling ->
Radiofysik
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Radiologi och bildbehandling ->
Strålningsbiologi
Postens nummer:
237917
Posten skapad:
2016-06-20 08:05

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