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Individuals with Metabolically Healthy Overweight/Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals

Författare och institution:
A. Pujia (-); C. Gazzaruso (-); Y. Ferro (-); E. Mazza (-); S. Maurotti (-); C. Russo (-); V. Lazzaro (-); Stefano Romeo (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); T. Montalcini (-)
Publicerad i:
Nutrients, 8 ( 1 )
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The mechanisms underlying the change in phenotype from metabolically healthy to metabolically unhealthy obesity are still unclear. The aim of this study is to investigate whether a difference in fasting fat utilization exists between overweight/obese individuals with a favorable cardiovascular risk profile and those with Metabolic Syndrome and Type 2 diabetes. Furthermore, we sought to explore whether there is an association between fasting fat utilization and insulin resistance. In this cross-sectional study, 172 overweight/obese individuals underwent a nutritional assessment. Those with fasting glucose >= 126 mg/dL or antidiabetic treatment were considered to be diabetics. If at least three of the NCEP criteria were present, they had Metabolic Syndrome, while those with less criteria were considered to be healthy overweight/obese. An indirect calorimetry was performed to estimate Respiratory Quotient, an index of nutrient utilization. A lower Respiratory Quotient (i.e., higher fat utilization) was found in healthy overweight/obese individuals than in those with Metabolic Syndrome and Type 2 diabetes (0.85 +/- 0.05; 0.87 +/- 0.06; 0.88 +/- 0.05 respectively, p = 0.04). The univariate and multivariable analysis showed a positive association between the Respiratory Quotient and HOMA-IR (slope in statistic (B) = 0.004; beta = 0.42; p = 0.005; 95% Confidence interval = 0.001-0.006). In this study, we find, for the first time, that the fasting Respiratory Quotient is significantly lower (fat utilization is higher) in individuals who are metabolically healthy overweight/obese than in those with metabolically unhealthy obesity. In addition, we demonstrated the association between fat utilization and HOMA-IR, an insulin resistance index.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
obesity, nutrition assessment, fat utilization, Metabolic Syndrome, metabolically unhealthy Obesity, glucagon-like peptide-1, type-2 diabetic-patients, intima-media, thickness, body-mass index, insulin-resistance, acid oxidation, skeletal-muscle, cardiovascular-disease, risk-factors, arterial-hypertension, Nutrition & Dietetics, ates of america, v104, p16480, hutz y, 1989, american journal of clinical nutrition, v50, p307, HUTZ Y, 1995, OBESITY RESEARCHWorkshop on Prevention of Obesity - Populations at Risk, Etiologic, neill g, 1988, international journal of obesity, v12, p455
Postens nummer:
Posten skapad:
2016-06-09 15:44

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