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Göteborgs universitets publikationer

Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models

Författare och institution:
S. Yakar (-); Olle Isaksson (Institutionen för medicin)
Publicerad i:
Growth Hormone & Igf Research, 28 s. 26-42
ISSN:
1096-6374
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum levels of GH/IGF-1 rise during pubertal growth and associate with peak bone acquisition, while during aging their levels decline and associate with bone loss. The GH/IGF-1 axis was extensively studied in numerous biological systems including rodent models and cell cultures. Both hormones act in an endocrine and autocrine/paracrine fashion and understanding their distinct and overlapping contributions to skeletal acquisition is still a matter of debate. GH and IGF-1 exert their effects on osteogenic cells via binding to their cognate receptor, leading to activation of an array of genes that mediate cellular differentiation and function. Both hormones interact with other skeletal regulators, such as sex steroids, thyroid hormone, and parathyroid hormone, to facilitate skeletal growth and metabolism. In this review we summarized several rodent models of the GH/IGF-1 axis and described key experiments that shed new light on the regulation of skeletal growth by the GH/IGF-1 axis. (C) 2015 Elsevier Ltd. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes
Nyckelord:
Growth hormone (GH), Growth hormone receptor (GHR), Insulin-like growth factor-1 (IGF-1), Growth, estrogen-receptor-alpha, igf-i-receptor, unloading induces resistance, periosteal bone-formation, factor-binding protein-1, hormone transgenic, mice, osteoblast-like cells, strain gradients correlate, nitric-oxide, synthase, acid-labile subunit, Cell Biology, Endocrinology & Metabolism, chiara tm, 1991, cell, v64, p849, wellbraxton l, 1993, role of insulin-like growth factors in the nervous systemsconf, wellbraxton l, 1993, genes & development, v7, p2609
Postens nummer:
237217
Posten skapad:
2016-06-02 13:27

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