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Göteborgs universitets publikationer

Trisomy 8 in Pediatric Acute Myeloid Leukemia. A NOPHO-AML Study.

Författare och institution:
Anne Cathrine Lund Laursen (-); Julie Damgaard Sandahl (-); Eigil Kjeldsen (-); Jonas Abrahamsson (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Peter Asdahl (-); Shau-Yin Ha (-); Jesper Heldrup (-); Kirsi Jahnukainen (-); Ólafur G Jónsson (-); Birgitte Lausen (-); Josefine Palle (-); Bernward Zeller (-); Erik Forestier (-); Henrik Hasle (-)
Publicerad i:
Genes, chromosomes & cancer, Epub ahead of print
ISSN:
1098-2264
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Trisomy 8 (+8) is a common cytogenetic aberration in acute myeloid leukemia (AML); however, the impact of +8 in pediatric AML is largely unknown. We retrospectively investigated 609 patients from the NOPHO-AML database to determine the clinical and cytogenetic characteristics of +8 in pediatric AML and to investigate its prognostic impact. Complete cytogenetic data were available in 596 patients (98%) aged 0-18 years, diagnosed from 1993 to 2012, and treated according to the NOPHO-AML 1993 and 2004 protocols in the Nordic countries and Hong Kong. We identified 86 patients (14%) with +8. Trisomy 8 was combined with other cytogenetic aberrations in 68 patients (11%) (+8 other) and in 18 patients (3%) it was the sole abnormality (+8 alone). Trisomy 8 was associated with FAB M5 (36%) but otherwise clinically comparable with non trisomy 8 patients. Trisomy 8 was favorable in patients of young age and with t(9;11). Trisomy 8 alone was associated with older age (median age 10.1 years), FAB M2 (33%), and FLT3-ITD mutations (58%). The 5-year event-free survival for patients with +8 alone was 50% and 5-year overall survival was 75%. In conclusion, +8 is one of the most common cytogenetic aberrations in pediatric AML. Trisomy 8 positive AML is a heterogeneous group and the majority of cases have additional cytogenetic aberrations. Patients with +8 alone differed from patients with +8 other and were associated with older age, FAB M2, and FLT3-ITD aberrations. There were no differences in survival despite the more frequent occurrence of FLT3-ITD in +8 alone. This article is protected by copyright. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Pediatrik
Postens nummer:
237171
Posten skapad:
2016-06-01 09:54
Posten ändrad:
2016-06-01 10:03

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