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Göteborgs universitets publikationer

A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women

Författare och institution:
P. Leandersson (-); G. Kalapotharakos (-); E. Henic (-); H. Borgfeldt (-); Max Petzold (Institutionen för medicin); G. Hoyer-Hansen (-); C. Borgfeldt (-)
Publicerad i:
Anticancer Research, 36 ( 3 ) s. 957-965
ISSN:
0250-7005
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Sammanfattning (abstract):
Background/Aim: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II. Patients and Methods: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) were analyzed in 350 patients with adnexal lesions. Results: The levels of suPAR(II-III), HE4, CA125 were all higher in EOC II than in EOC I, borderline and benign ovarian tumors. B7-H4 was increased in EOC II compared with benign ovarian tumors. The combination of suPAR(II-III), HE4, CA125 and age in premenopausal women discriminates EOC and borderline tumors from benign tumors to higher accuracy compared to the Risk of Ovarian Malignancy Algorithm (p=0.007). Conclusion: The biomarker panel suPAR(II-III), HE4, CA125 and age in premenopausal women improved discrimination of malignant and benign ovarian tumors. The plasma levels of B7-H4 were increased in patients with EOC II compared to those with benign ovarian tumors.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
CA125, uPAR, HE4, B7-H4, ROMA, ovarian neoplasm, survival analyses, cleaved forms, pelvic mass, he-4, pathogenesis, prediction, malignancy, prognosis, carcinoma, receptor, benign, Oncology
Postens nummer:
237146
Posten skapad:
2016-05-31 16:18

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