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Göteborgs universitets publikationer

Neuroendocrine neoplasms of the sinonasal region

Författare och institution:
D. Bell (-); E. Y. Hanna (-); R. S. Weber (-); F. DeMonte (-); A. Triantafyllou (-); J. S. Lewis (-); A. Cardesa (-); P. J. Slootweg (-); Göran Stenman (Sahlgrenska Cancer Center); D. R. Gnepp (-); K. O. Devaney (-); J. P. Rodrigo (-); A. Rinaldo (-); B. M. Wenig (-); W. H. Westra (-); J. A. Bishop (-); H. Hellquist (-); J. L. Hunt (-); K. Kusafuka (-); B. Perez-Ordonez (-); M. D. Williams (-); R. P. Takes (-); A. Ferlito (-)
Publicerad i:
Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 38 ( S1 ) s. E2259-E2266
ISSN:
1043-3074
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
neuroendocrine neoplasms, olfactory neuroblastoma, sinonasal carcinoma, immunohistochemistry, sinonasal undifferentiated carcinoma, undifferentiated carcinoma, olfactory neuroblastoma, multimodality, therapy, human-papillomavirus, prognostic-factors, esthesioneuroblastoma, management, differentiation, survival, head, Otorhinolaryngology, Surgery
Postens nummer:
237141
Posten skapad:
2016-05-31 15:41
Posten ändrad:
2016-06-01 10:20

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