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Göteborgs universitets publikationer

Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Författare och institution:
S. S. Li (-); A. Zhu (-); V. Benes (-); P. I. Costea (-); R. Hercog (-); F. Hildebrand (-); J. Huerta-Cepas (-); Max Nieuwdorp (Wallenberglaboratoriet); J. Salojarvi (-); A. Y. Voigt (-); G. Zeller (-); S. Sunagawa (-); W. M. de Vos (-); P. Bork (-)
Publicerad i:
Science, 352 ( 6285 ) s. 586-589
ISSN:
0036-8075
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
recurrent clostridium-difficile, human gut microbiome, ulcerative-colitis, bacteria
Postens nummer:
237102
Posten skapad:
2016-05-30 15:42

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