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Göteborgs universitets publikationer

The toxic effects of microcystin-LR on mouse lungs and alveolar type II epithelial cells

Författare och institution:
C. Wang (-); S. Gu (-); X. Q. Yin (-); M. M. Yuan (-); Zou Xiang (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Z. T. Li (-); H. H. Cao (-); X. N. Meng (-); K. B. Hu (-); X. D. Han (-)
Publicerad i:
Toxicon, 115 s. 81-88
ISSN:
0041-0101
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Objectives: Microcystin-leucine arginine (MC-LR) is produced by cyanobacteria and can accumulate in lungs through blood circulation. However, the effect of MC-LR on lung remains unclear. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse lung tissues and the influence of MC-LR on mouse alveolar type II epithelial cells (ATII cells). Methods: MC-LR was orally administered to mice at 0, 1, 10, and 40 mu g/L for 6 consecutive months and mouse lungs were obtained for histopathological and immunoblot analysis. ATII cells were cultured in various concentrations of MC-LR (0, 0.5, 5, 50, 500 nmol/L) for indicated time and the cell viability and proteins change were tested. Results: Our study revealed that the chronic, low-dose MC-LR exposure induced alveolar collapse and lung cell apoptosis as well as the breach of cell junction integrity. Furthermore, following treatment with MC-LR, ATII cells could uptake MC-LR, resulting in apoptosis and disruption of cell junction integrity. Conclusions: These data support the toxic potential of low-dose MC-LR in rendering chronic injury to lung tissues.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Biologiska vetenskaper
Nyckelord:
Microcystin-LR, Chronic low dose, Lung, Toxic, mesenchymal transition, inhibition, mechanisms, surfactant, liver, water, line, cyanotoxins, metastasis, activation, Pharmacology & Pharmacy, Toxicology
Postens nummer:
236990
Posten skapad:
2016-05-27 13:22

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