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Göteborgs universitets publikationer

L-arginine promotes gut hormone release and reduces food intake in rodents

Författare och institution:
A. Alamshah (-); A. K. McGavigan (-); E. Spreckley (-); J. S. Kinsey-Jones (-); A. Amin (-); I. R. Tough (-); H. C. O'Hara (-); A. Moolla (-); K. Banks (-); R. France (-); G. Hyberg (-); M. Norton (-); W. Cheong (-); Anders Lehmann (Institutionen för neurovetenskap och fysiologi); S. R. Bloom (-); H. M. Cox (-); K. G. Murphy (-)
Publicerad i:
Diabetes Obesity & Metabolism, 18 ( 5 ) s. 508-518
ISSN:
1462-8902
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Aims: To investigate the anorectic effect of L-arginine (L-Arg) in rodents. Methods: We investigated the effects of L-Arg on food intake, and the role of the anorectic gut hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), the G-protein-coupled receptor family C group 6 member A (GPRC6A) and the vagus nerve in mediating these effects in rodents. Results: Oral gavage of L-Arg reduced food intake in rodents, and chronically reduced cumulative food intake in diet-induced obese mice. Lack of the GPRC6A in mice and subdiaphragmatic vagal deafferentation in rats did not influence these anorectic effects. L-Arg stimulated GLP-1 and PYY release in vitro and in vivo. Pharmacological blockade of GLP-1 and PYY receptors did not influence the anorectic effect of L-Arg. L-Arg-mediated PYY release modulated net ion transport across the gut mucosa. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) administration of L-Arg suppressed food intake in rats. Conclusions: L-Arg reduced food intake and stimulated gut hormone release in rodents. The anorectic effect of L-Arg is unlikely to be mediated by GLP-1 and PYY, does not require GPRC6A signalling and is not mediated via the vagus. I.c.v. and i.p. administration of L-Arg suppressed food intake in rats, suggesting that L-Arg may act on the brain to influence food intake. Further work is required to determine the mechanisms by which L-Arg suppresses food intake and its utility in the treatment of obesity.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes ->
Endokrinologi
Nyckelord:
animal pharmacology, body composition, energy regulation, GLP-1, obesity therapy, amino acid receptor, peptide-yy, nitric-oxide, body-weight, central, mechanisms, insulin-secretion, stimulates glp-1, gprc6a receptor, vagal, afferents, neuropeptide-y, Endocrinology & Metabolism
Postens nummer:
236909
Posten skapad:
2016-05-25 14:21
Posten ändrad:
2016-05-25 14:21

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