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Göteborgs universitets publikationer

When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks?

Författare och institution:
John Clemens (-); Jan Holmgren (Institutionen för biomedicin)
Publicerad i:
Cholera Outbreaks , 379 s. 231-258
ISSN:
0070-217X
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2014
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Cholera continues to be a major global health problem, at times causing major and prolonged outbreaks in both endemic and nonendemic settings in developing countries. While improved water quality, sanitation, and hygiene (WASH) will provide the ultimate solution to prevention of this disease burden, this is a far-off goal for most developing countries. Oral cholera vaccines (OCVs) have been demonstrated to be effective in the control of cholera outbreaks, and constitute useful tools to be used in conjunction with efforts to improve WASH. Two killed OCVs are prequalified by WHO for purchase by UN agencies for international use. Recently, WHO has launched a global stockpile of killed OCVs for use to control outbreaks. Rational deployment of OCV from this stockpile will require consideration of costs, feasibility, disease epidemiology, and the protective characteristics of the vaccine deployed, as well as effective and rapid coordination of processes and logistics used to make decisions on deployment and delivery of the vaccine to the population in need. Despite not having data on all the questions of relevance as to how to use OCVs to control cholera outbreaks in different settings, there is clearly more than enough evidence to initiate their use, as answers to remaining questions and refinement of policies will mainly come with experience.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
MEDICIN OCH HÄLSOVETENSKAP ->
Hälsovetenskaper
Nyckelord:
KILLED WHOLE-CELL, TOXIN-B-SUBUNIT, CVD 103-HGR, FIELD TRIAL, VACCINATION STRATEGIES, COST-EFFECTIVENESS, MASS VACCINATION, DEVELOPING-WORLD, IMMUNIZATION, BANGLADESH, Infectious Diseases, Microbiology, CKET CO, 1992, JOURNAL OF INFECTIOUS DISEASES, V166, P837, B BC, 1986, BULLETIN OF THE WORLD HEALTH ORGANIZATION, V64, P127
Postens nummer:
235892
Posten skapad:
2016-05-04 10:20
Posten ändrad:
2016-05-13 11:02

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