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Göteborgs universitets publikationer

PET Imaging of Tau Deposition in the Aging Human Brain

Författare och institution:
Michael Schöll (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering); S. N. Lockhart (-); D. R. Schonhaut (-); J. P. O'Neil (-); M. Janabi (-); R. Ossenkoppele (-); S. L. Baker (-); J. W. Vogel (-); J. Faria (-); H. D. Schwimmer (-); G. D. Rabinovici (-); W. J. Jagust (-)
Publicerad i:
Neuron, 89 ( 5 ) s. 971-982
ISSN:
0896-6273
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent F-18-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and beta-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical b-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and beta-amyloid deposition.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Neurovetenskaper
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Neurologi
Nyckelord:
mild cognitive impairment, alzheimers-disease, neurofibrillary tangles, episodic memory, cerebrospinal-fluid, national institute, age, categories, senile plaques, amyloid-beta, a-beta, Neurosciences & Neurology
Postens nummer:
235825
Posten skapad:
2016-05-03 13:09
Posten ändrad:
2016-05-03 13:10

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