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Göteborgs universitets publikationer

High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study

Författare och institution:
Sejla Brkic (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Bo Söderpalm (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Anna Söderpalm Gordh (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi)
Publicerad i:
Pharmacology Biochemistry and Behavior, 143 s. 65-72
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Aims: The present study was designed to examine the relationship between high and low cortisol response to an acute stressful situation and the subjective effects after different doses of alcohol, in healthy social drinkers. Method: Sixty-four subjects (32 men and 32 women) participated in one laboratory session. They performed a modified version of the Trier Social Stress Test (TSST) immediately before consumption of either placebo or alcohol (0.2, 0.4 or 0.8 g/kg). Subjects in each dose group were then divided into high (HCR; n = 32) or low (LCR; n = 32) cortisol responders. Primary dependent measures were self-report questionnaires of mood. Results: The HCR reported increased ratings on Sedation on the Biphasic Alcohol Effects Scale (BAES) with increased dose in comparison with the LCR. This increase in sedation also correlated to the increase in cortisol levels. Conclusion: We conclude that a high cortisol response to stress modulates the subjective response to alcohol, dose-dependently. HCR subjects experience increased sedative effects of alcohol after consumption of higher doses of alcohol following stress compared to LCR subjects.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
Alcohol, Stress, Social drinkers, Cortisol response, Subjective effects, TSST, ethanol-consumption, psychosocial stress, family-history, dependent, individuals, healthy-subjects, social stress, reactivity, corticosterone, humans, intoxication, Behavioral Sciences
Postens nummer:
Posten skapad:
2016-04-18 09:42

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