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Cdk1 activity acts as a quantitative platform for coordinating cell cycle progression with periodic transcription

Författare och institution:
Gabor Banyai (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Feriel Baïdi (-); Damien Coudreuse (-); Zsolt Szilagyi (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi)
Publicerad i:
Nature Communications, 7 s. 11161
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Cell proliferation is regulated by cyclin-dependent kinases (Cdks) and requires the periodic expression of particular gene clusters in different cell cycle phases. However, the interplay between the networks that generate these transcriptional oscillations and the core cell cycle machinery remains largely unexplored. In this work, we use a synthetic regulable Cdk1 module to demonstrate that periodic expression is governed by quantitative changes in Cdk1 activity, with different clusters directly responding to specific activity levels. We further establish that cell cycle events neither participate in nor interfere with the Cdk1-driven transcriptional program, provided that cells are exposed to the appropriate Cdk1 activities. These findings contrast with current models that propose self-sustained and Cdk1-independent transcriptional oscillations. Our work therefore supports a model in which Cdk1 activity serves as a quantitative platform for coordinating cell cycle transitions with the expression of critical genes to bring about proper cell cycle progression.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper
Biologiska vetenskaper ->
Postens nummer:
Posten skapad:
2016-04-13 10:03
Posten ändrad:
2016-05-03 08:34

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