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Göteborgs universitets publikationer

Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of (161)Tb-folate and (177)Lu-folate.

Författare och institution:
Stephanie Haller (-); Giovanni Pellegrini (-); Christiaan Vermeulen (-); Nicholas P van der Meulen (-); Ulli Köster (-); Peter Bernhardt (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik); Roger Schibli (-); Cristina Müller (-)
Publicerad i:
EJNMMI research, 6 ( 1 ) s. 13
ISSN:
2191-219X
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The radiolanthanide (161)Tb has, in recent years, attracted increasing interest due to its favorable characteristics for medical application. (161)Tb exhibits similar properties to the widely-used therapeutic radionuclide (177)Lu. In contrast to (177)Lu, (161)Tb yields a significant number of short-ranging Auger/conversion electrons (≤50 keV) during its decay process. (161)Tb has been shown to be more effective for tumor therapy than (177)Lu if applied using the same activity. The purpose of this study was to investigate long-term damage to the kidneys after application of (161)Tb-folate and compare it to the renal effects caused by (177)Lu-folate.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Radiologi och bildbehandling ->
Radiofysik
Nyckelord:
Radionuclide therapy, Tb-161, Lu-177, Auger/conversion electrons, Radionephropathy, Kidney, TUMOR-THERAPY, NORMAL-TISSUES, IN-VITRO, FOLATE, CANCER, LU-177, TB-161, MECHANISMS, CONJUGATE, DOSIMETRY
Postens nummer:
234405
Posten skapad:
2016-04-08 14:33
Posten ändrad:
2016-05-02 10:33

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