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Göteborgs universitets publikationer

Aortic Regurgitation Is Common in Ankylosing Spondylitis: Time for Routine Echocardiography Evaluation?

Författare och institution:
Eva Klingberg (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Bente Grüner Sveälv (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Margareta Scharin Täng (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Odd Bech-Hanssen (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Helena Forsblad d'Elia (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Lennart Bergfeldt (Institutionen för medicin, avdelningen för molekylär och klinisk medicin)
Publicerad i:
Journal of the American Medical Association, 128 ( 11 ) s. 1244-50
ISSN:
0098-7484
E-ISSN:
1538-3598
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
OBJECTIVES: The aim of this study was to assess the prevalence of aortic regurgitation and any relation to disease activity and specific human leukocyte antigen (HLA)-B27 subtypes in patients with ankylosing spondylitis. METHODS: Transthoracic echocardiography was performed in 187 patients (105 men), mean age (SD) 50 (13) years, and mean disease duration 24 (13) years, and was related to demographic, clinical, radiographic, electrocardiographic, and laboratory data. RESULTS: Aortic regurgitation was found in 34 patients (18%; 95% confidence interval [CI], 12%-24%): mild in 24, moderate in 9, and severe in one. The prevalence was significantly higher than expected from population data. Conduction system abnormalities were documented in 25 patients (13%; 95% CI, 8%-18%), and significantly more likely in the presence of aortic regurgitation (P = .005), which was related to increasing age and longstanding disease, and increased from ~20% in the 50s to 55% in the 70s. It was also independently associated with disease duration, with higher modified Stoke Ankylosing Spondylitis Spine Score, and with a history of anterior uveitis. HLA-B27 was present in similar proportions in the presence vs absence of aortic regurgitation. For comparison, clinically significant coronary artery disease was present in 9 patients (5%; 95% CI, 2%-8%). CONCLUSION: Patients with ankylosing spondylitis frequently have cardiac abnormalities, but they more often consist of disease-related aortic regurgitation or conduction system abnormalities than manifestations of atherosclerotic heart disease. Because aortic regurgitation or conduction abnormalities might cause insidious symptoms not easily interpreted as of cardiac origin, we suggest that both electrocardiography and echocardiography evaluation should be part of the routine management of patients with ankylosing spondylitis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
Ankylosing spondylitis; Aortic regurgitation; Disease activity; Echocardiography; Electrocardiography
Postens nummer:
234294
Posten skapad:
2016-04-07 09:15
Posten ändrad:
2016-08-31 08:52

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