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Göteborgs universitets publikationer

Mitral regurgitation quantification by cardiovascular magnetic resonance: a comparison of indirect quantification methods

Författare och institution:
Christian Lars Polte (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Odd Bech-Hanssen (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Åse (Allansdotter) Johnsson (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiologi); Sinsia Gao (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Kerstin M Lagerstrand (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik)
Publicerad i:
The International Journal of Cardiovascular Imaging, 31 ( 6 ) s. 1223-31
ISSN:
1569-5794
E-ISSN:
1573-0743
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2015
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Quantification of mitral regurgitation (MR) using cardiovascular magnetic resonance can be achieved by three indirect methods. The aims of the study were to determine their agreement, observer variability and effect on grading MR severity. The study comprised 16 healthy volunteers and 36 MR patients. Quantification was performed using the 'standard' [left ventricular stroke volume (LVSV)-aortic forward flow (AoFF)], 'volumetric' [LVSV-right ventricular stroke volume (RVSV)] and 'flow' method [mitral inflow (MiIF)-AoFF]. In healthy volunteers without MR, LVSV was larger than AoFF (mean difference ±SD: 12 ± 6 ml, P < 0.0001). Only small differences were found between LVSV-RVSV (3 ± 6 ml) and MiIF-AoFF (1 ± 5 ml). In patients, mitral regurgitant volumes (MRVs)/fractions (MRFs) were larger (P < 0.0001) using the 'standard' method (90 ± 31 ml/51 ± 11%) compared with the 'volumetric' (76 ± 30 ml/42 ± 11%) and 'flow' method (70 ± 32 ml/44 ± 15%). Inter-observer variability was lowest for the 'flow' and highest for the 'volumetric' method, while intra-observer variability was similar for all three methods. In 29 operated patients with severe MR, MRVs were above the guideline threshold (≥60 ml) in 100, 86 and 83% of the cases, and MRFs were above the threshold (≥50%) in 76, 32 and 48% of the cases, when using the 'standard', 'volumetric' and 'flow' method respectively. In conclusion, the choice of method can affect the grading of MR severity and thereby eventually the clinical decision-making and timing of surgery.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin
Nyckelord:
Cardiovascular magnetic resonance; mitral regurgitation
Postens nummer:
234293
Posten skapad:
2016-04-07 09:09
Posten ändrad:
2016-06-23 13:23

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