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Göteborgs universitets publikationer

Serum nuclear magnetic resonance-based metabolomics and outcome in diffuse large B-cell lymphoma patients - a pilot study.

Författare och institution:
Martin Stenson (Institutionen för medicin); Anders Pedersen (Svenskt NMR-centrum vid Göteborgs universitet); Sverker Hasselblom (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Herman Nilsson-Ehle (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); Bengt Göran Karlsson (Svenskt NMR-centrum vid Göteborgs universitet); Rui Pinto (-); Per-Ola Andersson (Institutionen för medicin)
Publicerad i:
Leukemia & lymphoma, 57 ( 8 ) s. 1814-1822
ISSN:
1029-2403
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
The prognosis for diffuse large B-cell lymphoma (DLBCL) patients with early relapse or refractory disease is dismal. To determine if clinical outcome correlated to diverse serum metabolomic profiles, we used (1)H nuclear magnetic resonance (NMR) spectroscopy and compared two groups of DLBCL patients treated with immunochemotherapy: i) refractory/early relapse (REF/REL; n=27) and ii) long-term progression-free (CURED; n = 60). A supervised multivariate analysis showed a separation between the groups. Among discriminating metabolites higher in the REF/REL group were the amino acids lysine and arginine, the degradation product cadaverine and a compound in oxidative stress (2-hydroxybutyrate). In contrast, the amino acids aspartate, valine and ornithine, and a metabolite in the glutathione cycle, pyroglutamate, were higher in CURED patients. Together, our data indicate that NMR-based serum metabolomics can identify a signature for DLBCL patients with high-risk of failing immunochemotherapy, prompting for larger validating studies which could lead to more individualized treatment of this disease.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Biologiska vetenskaper
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Hematologi
Postens nummer:
234223
Posten skapad:
2016-04-06 13:49
Posten ändrad:
2016-09-26 12:56

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