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Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis.

Författare och institution:
Malin Erlandsson (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Roberto Doria Medina (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Sofia Silfverswärd Lindblad (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Maria Bokarewa (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Mediators of inflammation, 2016 s. 3082820
ISSN:
1466-1861
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2016
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Objectives. Smoking is pathogenic for rheumatoid arthritis (RA) being tightly connected to the genetic and serological risk factors for this disease. This study aims to understand connections between cigarette smoking and serum levels of IGF1 and adipokines in RA. Methods. Serum levels of IGF1 and adipokines leptin, adiponectin, resistin, and visfatin were measured in two independent cohorts of RA patients from Gothenburg (n = 350) and Leiden (n = 193). An association of these parameters with smoking was tested in a direct comparison and proved by bivariate correlation analysis. The obtained associations were further tested in multivariate regression models where the confounders (age, gender, disease duration, and BMI) were controlled. Results. The smokers had significantly lower serum levels of IGF1, adiponectin, and leptin compared to never smokers. In regression analysis, smoking and low leptin, but not adiponectin, were associated and predicted low IGF1. Additionally, high disease activity and high BMI increased the probability of low leptin. Conclusions. The study indicates cigarette smoking as an important cause of a relative IGF1 and leptin deficiency in RA patients. This novel association between smoking and hypoleptinemia may be of importance for long-term prognosis of RA and for prediction of comorbidities.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Endokrinologi och diabetes ->
Endokrinologi
MEDICIN OCH HÄLSOVETENSKAP ->
Klinisk medicin ->
Reumatologi och inflammation
Nyckelord:
IGF1, leptin, rheumatoid arthritis, smoking, cohort studies
Postens nummer:
234208
Posten skapad:
2016-04-06 13:12
Posten ändrad:
2016-04-28 15:47

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