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Göteborgs universitets publikationer

Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia

Författare och institution:
Frida Ewald Sander (Sahlgrenska Cancer Center); Anna Rydström (Sahlgrenska Cancer Center); Elin Bernson (Sahlgrenska Cancer Center); Roberta Kiffin (Sahlgrenska Cancer Center); Rebecca E Riise (Sahlgrenska Cancer Center); Johan Aurelius (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); H. Anderson (-); Mats Brune (Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition); R. Foa (-); Kristoffer Hellstrand (Sahlgrenska Cancer Center); Fredrik B Thorén (Sahlgrenska Cancer Center); Anna Martner (Sahlgrenska Cancer Center)
Publicerad i:
Oncotarget, 7 ( 7 ) s. 7586-7596
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Preventing relapse after chemotherapy remains a challenge in acute myeloid leukemia (AML). Eighty-four non-transplanted AML patients in first complete remission received relapse-preventive immunotherapy with histamine dihydrochloride and low-dose interleukin-2 in an international phase IV trial (; NCT01347996). Blood samples were drawn during cycles of immunotherapy and analyzed for CD8(+) (cytotoxic) T cell phenotypes in blood. During the first cycle of therapy, a re-distribution of cytotoxic T cells was observed comprising a reduction of T effector memory cells and a concomitant increase of T effector cells. The dynamics of T cell subtypes during immunotherapy prognosticated relapse and survival, in particular among older patients and remained significantly predictive of clinical outcome after correction for potential confounders. Presence of CD8(+) T cells with specificity for leukemia-associated antigens identified patients with low relapse risk. Our results point to novel aspects of T cell-mediated immunosurveillance in AML and provide conceivable biomarkers in relapse-preventive immunotherapy.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
acute myeloid leukemia, immunotherapy, cytotoxic T cells, antigen-specific T cells, Immunology and, histamine dihydrochloride, transplantation, memory, differentiation, interleukin-2, lymphocytes, maintenance, remission, responses, effector, Oncology, Cell Biology
Postens nummer:
Posten skapad:
2016-03-18 15:25
Posten ändrad:
2016-03-30 14:58

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