transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Epigenetic Modifications of Histones in Periodontal Disease

Författare och institution:
M. D. Martins (-); Y. Jiao (-); Lena Larsson (Institutionen för odontologi, sektion 2); L. O. Almeida (-); C. Garaicoa-Pazmino (-); J. M. Le (-); C. H. Squarize (-); N. Inohara (-); W. V. Giannobile (-); R. M. Castilho (-)
Publicerad i:
Journal of Dental Research, 95 ( 2 ) s. 215-222
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Periodontitis is a chronic infectious disease driven by dysbiosis, an imbalance between commensal bacteria and the host organism. Periodontitis is a leading cause of tooth loss in adults and occurs in about 50% of the US population. In addition to the clinical challenges associated with treating periodontitis, the progression and chronic nature of this disease seriously affect human health. Emerging evidence suggests that periodontitis is associated with mechanisms beyond bacteria-induced protein and tissue degradation. Here, we hypothesize that bacteria are able to induce epigenetic modifications in oral epithelial cells mediated by histone modifications. In this study, we found that dysbiosis in vivo led to epigenetic modifications, including acetylation of histones and downregulation of DNA methyltransferase 1. In addition, in vitro exposure of oral epithelial cells to lipopolysaccharides resulted in histone modifications, activation of transcriptional coactivators, such as p300/CBP, and accumulation of nuclear factor-kappa B (NF-kappa B). Given that oral epithelial cells are the first line of defense for the periodontium against bacteria, we also evaluated whether activation of pathogen recognition receptors induced histone modifications. We found that activation of the Toll-like receptors 1, 2, and 4 and the nucleotide-binding oligomerization domain protein 1 induced histone acetylation in oral epithelial cells. Our findings corroborate the emerging concept that epigenetic modifications play a role in the development of periodontitis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
NOD1, TLRs, lipopolysaccharides, histone acetylation, oral mucosa, bacteria, nf-kappa-b, outer-membrane vesicles, toll-like receptors, porphyromonas-gingivalis, gene-expression, bacterial, lipopolysaccharides, pseudomonas-aeruginosa, bone loss, dysbiosis, infection, Dentistry, Oral Surgery & Medicine
Postens nummer:
Posten skapad:
2016-02-25 14:43

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007